[Related publication] "Nanoplasmonic Rapid Antimicrobial-resistance Point-of-care Identification Device: RAPIDx", Advanced Healthcare Materials (IF:10.0) (Selected for Inside Back Cover), 2024.08. [Link].

Point-of-Care (POC) diagnostic platforms are essential for rapid, accessible healthcare, especially in resource-limited settings. Designing these devices requires understanding complex interactions between fluid flow, biomolecule transport, and sensor response at multiple scales.

Our group develops a multiscale and multiphysics design framework for optimizing POC systems. We integrate wave optics, heat transfer, microfluidics, and particle tracing modeling to predict device performance under real-world conditions. This approach enables the development of compact, low-power, and highly sensitive diagnostic devices—paving the way for reliable, field-deployable healthcare solutions.

Plasmonic biosensors provide high sensitivity for biomolecular detection by exploiting localized surface plasmon resonance (LSPR) in nanostructured metallic materials. To optimize their performance, it is essential to understand the interplay between electromagnetic fields, molecular interactions, and device geometry.

Our group develops a multiscale and multiphysics simulation framework that combines electromagnetic analysis with molecular-scale transport and reaction modeling. This approach enables the precise tuning of nanostructure shape, gap distance, and surface chemistry to enhance signal strength and sensing specificity in realistic biological environments.

[Related publication] "High-spatial and colourimetric imaging of histone modifications in single senescent cells using plasmonic nanoprobes", Nature Communications (IF: 17.694), 2021.10. [Link]

[Related publication] "Adjustable and versatile 3D tumor spheroid culture platform with interfacial elastomeric wells", ACS Applied Materials & Interfaces (IF: 10.383), 2020. [Link] 

"Characterization of passive microfluidic mixer with a three-dimensional zig-zag channel for cryo-EM sampling", Chemical Engineering Science (IF:4.7), 2023. [Link]

Three-dimensional (3D) spheroid cultures offer enhanced physiological relevance compared to conventional 2D models, making them well-suited for studying tissue behavior, drug response, and cell–cell interactions. Our group develops platforms for controlled and reproducible spheroid formation, enabling scalable and long-term in vitro modeling of complex biological systems.

Separately, we design microfluidic mixing systems optimized for efficient and homogeneous mixing of reagents under continuous flow. By tuning channel geometries and flow conditions, these systems support precise biochemical stimulation and real-time control of reaction environments in lab-on-a-chip applications.